Modeling disease in vivo with CRISPR/Cas9

بواسطة Dow, Lukas E.
الحاوية / القاعدة Trends Mol Med (2015)

Life in the Fast Lane: Mammalian Disease Models in the Genomics Era

بواسطة Dow, Lukas E., Lowe, Scott W.
منشور في 2012

Somatic Genome Editing Goes Viral

بواسطة Zafra, Maria Paz, Dow, Lukas E.
الحاوية / القاعدة Trends Mol Med (2016)

Wnt Signaling and Colorectal Cancer

بواسطة Schatoff, Emma M., Leach, Benjamin I., Dow, Lukas E.
الحاوية / القاعدة Curr Colorectal Cancer Rep (2017)

Base editing the mammalian genome

بواسطة Schatoff, Emma M, Zafra, Maria Paz, Dow, Lukas E
الحاوية / القاعدة Methods (2019)

Immunofluorescent Staining of Mouse Intestinal Stem Cells

بواسطة O’Rourke, Kevin P., Dow, Lukas E, Lowe, Scott W
الحاوية / القاعدة Bio Protoc (2016)

Isolation, Culture, and Maintenance of Mouse Intestinal Stem Cells

بواسطة O’Rourke, Kevin P., Ackerman, Sarah, Dow, Lukas E, Lowe, Scott W
الحاوية / القاعدة Bio Protoc (2016)

EpCAM (CD326) Regulates Intestinal Epithelial Integrity and Stem Cells via Rho-Associated Kinase

بواسطة Ouchi, Takeshi, Morimura, Sohshi, Dow, Lukas E., Miyoshi, Hiroyuki, Udey, Mark C.
الحاوية / القاعدة Cells (2021)

Creating Transgenic shRNA Mice by Recombinase-Mediated Cassette Exchange

بواسطة Premsrirut, Prem K., Dow, Lukas E., Park, Youngkyu, Hannon, Gregory J., Lowe, Scott W.
منشور في 2013

Preclinical murine platform to evaluate therapeutic countermeasures against radiation-induced gastrointestinal syndrome

بواسطة Romesser, Paul B., Kim, Amanda S., Jeong, Jeho, Mayle, Allison, Dow, Lukas E., Lowe, Scott W.
الحاوية / القاعدة Proc Natl Acad Sci U S A (2019)

GO: a functional reporter system to identify and enrich base editing activity

بواسطة Katti, Alyna, Foronda, Miguel, Zimmerman, Jill, Diaz, Bianca, Zafra, Maria Paz, Goswami, Sukanya, Dow, Lukas E
الحاوية / القاعدة Nucleic Acids Res (2020)

R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine

بواسطة Han, Teng, Schatoff, Emma M., Murphy, Charles, Zafra, Maria Paz, Wilkinson, John E., Elemento, Olivier, Dow, Lukas E.
الحاوية / القاعدة Nat Commun (2017)

Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi

بواسطة Zuber, Johannes, McJunkin, Katherine, Fellmann, Christof, Dow, Lukas E, Taylor, Meredith J, Hannon, Gregory J, Lowe, Scott W
منشور في 2010

A modular and flexible ESC-based mouse model of pancreatic cancer

بواسطة Saborowski, Michael, Saborowski, Anna, Morris, John P., Bosbach, Benedikt, Dow, Lukas E., Pelletier, Jerry, Klimstra, David S., Lowe, Scott W.
منشور في 2014

Reversible suppression of an essential gene in adult mice using transgenic RNA interference

بواسطة McJunkin, Katherine, Mazurek, Anthony, Premsrirut, Prem K., Zuber, Johannes, Dow, Lukas E., Simon, Janelle, Stillman, Bruce, Lowe, Scott W.
منشور في 2011

Conditional Reverse Tet-Transactivator Mouse Strains for the Efficient Induction of TRE-Regulated Transgenes in Mice

بواسطة Dow, Lukas E., Nasr, Zeina, Saborowski, Michael, Ebbesen, Saya H., Manchado, Eusebio, Tasdemir, Nilgun, Lee, Teresa, Pelletier, Jerry, Lowe, Scott W.
منشور في 2014

The Polarity Protein Scribble Regulates Myelination and Remyelination in the Central Nervous System

بواسطة Jarjour, Andrew A., Boyd, Amanda, Dow, Lukas E., Holloway, Rebecca K., Goebbels, Sandra, Humbert, Patrick O., Williams, Anna, ffrench-Constant, Charles
الحاوية / القاعدة PLoS Biol (2015)

Apc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer

بواسطة Dow, Lukas E, O’Rourke, Kevin P, Simon, Janelle, Tschaharganeh, Darjus F, van Es, Johan H, Clevers, Hans, Lowe, Scott W
الحاوية / القاعدة Cell (2015)

Inducible hepatic expression of CREBH mitigates diet-induced obesity, insulin resistance, and hepatic steatosis in mice

بواسطة Krumm, Christopher S., Xu, Xu, Bare, Curtis J., Holman, Corey D., Kersten, Sander, Dow, Lukas E., Lee, Ann-Hwee, Cohen, David E.
الحاوية / القاعدة J Biol Chem (2021)

Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition

بواسطة Bolden, Jessica E., Tasdemir, Nilgun, Dow, Lukas E., van Es, Johan H., Wilkinson, John E., Zhao, Zhen, Clevers, Hans, Lowe, Scott W.
الحاوية / القاعدة Cell Rep (2014)