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Reversible suppression of an essential gene in adult mice using transgenic RNA interference
RNAi has revolutionized loss-of-function genetics by enabling sequence-specific suppression of virtually any gene. Furthermore, tetracycline response elements (TRE) can drive expression of short hairpin RNAs (shRNAs) for inducible and reversible target gene suppression. Here, we demonstrate the feas...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3084121/ https://ncbi.nlm.nih.gov/pubmed/21482754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104097108 |
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