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Reversible suppression of an essential gene in adult mice using transgenic RNA interference
RNAi has revolutionized loss-of-function genetics by enabling sequence-specific suppression of virtually any gene. Furthermore, tetracycline response elements (TRE) can drive expression of short hairpin RNAs (shRNAs) for inducible and reversible target gene suppression. Here, we demonstrate the feas...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3084121/ https://ncbi.nlm.nih.gov/pubmed/21482754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104097108 |
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