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Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi
Short hairpin RNAs (shRNAs) are versatile tools for analyzing loss-of-function phenotypes in vitro and in vivo(1). However, their use for studying genes involved in proliferation and survival, which are potential therapeutic targets in cancer and other diseases, is confounded by the strong selective...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3394154/ https://ncbi.nlm.nih.gov/pubmed/21131983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1720 |
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