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Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi

Short hairpin RNAs (shRNAs) are versatile tools for analyzing loss-of-function phenotypes in vitro and in vivo(1). However, their use for studying genes involved in proliferation and survival, which are potential therapeutic targets in cancer and other diseases, is confounded by the strong selective...

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Библиографические подробности
Главные авторы: Zuber, Johannes, McJunkin, Katherine, Fellmann, Christof, Dow, Lukas E, Taylor, Meredith J, Hannon, Gregory J, Lowe, Scott W
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394154/
https://ncbi.nlm.nih.gov/pubmed/21131983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1720
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