In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer

In solid tumors, resistance to therapy inevitably develops upon treatment with cytotoxic drugs or molecularly targeted therapies. Here, we describe a system that enables pooled shRNA screening directly in mouse hepatocellular carcinomas (HCC) in vivo to identify genes likely to be involved in therap...

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Pubblicato in:Nat Med
Autori principali: Rudalska, Ramona, Dauch, Daniel, Longerich, Thomas, McJunkin, Katherine, Wuestefeld, Torsten, Kang, Tae-Won, Hohmeyer, Anja, Pesic, Marina, Leibold, Josef, von Thun, Anne, Schirmacher, Peter, Zuber, Johannes, Weiss, Karl-Heinz, Powers, Scott, Malek, Nisar P, Eilers, Martin, Sipos, Bence, Lowe, Scott W, Geffers, Robert, Laufer, Stefan, Zender, Lars
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587571/
https://ncbi.nlm.nih.gov/pubmed/25216638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3679
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