An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer

Cancers are highly heterogeneous and contain many passenger and driver mutations. To functionally identify tumor suppressor genes relevant to human cancer, we compiled pools of short harpin RNAs (shRNAs) targeting the mouse orthologs of genes recurrently deleted in a series of human hepatocellular c...

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Autors principals: Zender, Lars, Xue, Wen, Zuber, Johannes, Semighini, Camile P., Krasnitz, Alexander, Ma, Beicong, Zender, Peggy, Kubicka, Stefan, Luk, John M., Schirmacher, Peter, McCombie, Richard W., Wigler, Michael, Hicks, James, Hannon, Gregory J., Powers, Scott, Lowe, Scott W.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990916/
https://ncbi.nlm.nih.gov/pubmed/19012953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.09.061
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