Functional Identification of Tumor Suppressor Genes Through an in vivo RNA Interference Screen in a Mouse Lymphoma Model

Short hairpin RNAs (shRNAs) capable of stably suppressing gene function by RNA interference (RNAi) can mimic tumor suppressor gene loss in mice. By selecting for shRNAs capable of accelerating lymphomagenesis in a well-characterized mouse lymphoma model, we identified over ten candidate tumor suppre...

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Bibliografiske detaljer
Main Authors: Bric, Anka, Miething, Cornelius, Bialucha, Carl Uli, Scuoppo, Claudio, Zender, Lars, Krasnitz, Alexander, Xuan, Zhenyu, Zuber, Johannes, Wigler, Michael, Hicks, James, McCombie, Richard W., Hemann, Michael T., Hannon, Gregory J., Powers, Scott, Lowe, Scott W.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829755/
https://ncbi.nlm.nih.gov/pubmed/19800577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.08.015
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