A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions

The large chromosomal deletions frequently observed in cancer genomes are often thought to arise as a “two-hit” mechanism in the process of tumor-suppressor gene (TSG) inactivation. Using a murine model system of hepatocellular carcinoma (HCC) and in vivo RNAi, we test an alternative hypothesis, tha...

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Detalhes bibliográficos
Main Authors: Xue, Wen, Kitzing, Thomas, Roessler, Stephanie, Zuber, Johannes, Krasnitz, Alexander, Schultz, Nikolaus, Revill, Kate, Weissmueller, Susann, Rappaport, Amy R., Simon, Janelle, Zhang, Jack, Luo, Weijun, Hicks, James, Zender, Lars, Wang, Xin Wei, Powers, Scott, Wigler, Michael, Lowe, Scott W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361457/
https://ncbi.nlm.nih.gov/pubmed/22566646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206062109
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