DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma

Deletions on chromosome 8p are common in human tumors, suggesting that one or more tumor suppressor genes reside in this region. Deleted in Liver Cancer 1 (DLC1) encodes a Rho-GTPase activating protein and is a candidate 8p tumor suppressor. We show that DLC1 knockdown cooperates with Myc to promote...

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Detalhes bibliográficos
Main Authors: Xue, Wen, Krasnitz, Alexander, Lucito, Robert, Sordella, Raffaella, VanAelst, Linda, Cordon-Cardo, Carlos, Singer, Stephan, Kuehnel, Florian, Wigler, Michael, Powers, Scott, Zender, Lars, Lowe, Scott W.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2418580/
https://ncbi.nlm.nih.gov/pubmed/18519636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1672608
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