MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia

Recurring deletions of chromosome 7 and 7q [−7/del(7q)] occur in myelodysplastic syndromes and acute myeloid leukemia (AML) and are associated with poor prognosis. However, the identity of functionally relevant tumor suppressors on 7q remains unclear. Using RNAi and CRISPR/Cas9 approaches, we show t...

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Détails bibliographiques
Auteurs principaux: Chen, Chong, Liu, Yu, Rappaport, Amy R., Kitzing, Thomas, Schultz, Nikolaus, Zhao, Zhen, Shroff, Aditya S., Dickins, Ross A., Vakoc, Christopher R., Bradner, James E., Stock, Wendy, LeBeau, Michelle M., Shannon, Kevin M., Kogan, Scott, Zuber, Johannes, Lowe, Scott W.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4206212/
https://ncbi.nlm.nih.gov/pubmed/24794707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.03.016
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