An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer

Cancers are highly heterogeneous and contain many passenger and driver mutations. To functionally identify tumor suppressor genes relevant to human cancer, we compiled pools of short harpin RNAs (shRNAs) targeting the mouse orthologs of genes recurrently deleted in a series of human hepatocellular c...

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Main Authors: Zender, Lars, Xue, Wen, Zuber, Johannes, Semighini, Camile P., Krasnitz, Alexander, Ma, Beicong, Zender, Peggy, Kubicka, Stefan, Luk, John M., Schirmacher, Peter, McCombie, Richard W., Wigler, Michael, Hicks, James, Hannon, Gregory J., Powers, Scott, Lowe, Scott W.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990916/
https://ncbi.nlm.nih.gov/pubmed/19012953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.09.061
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