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Differential interleukin-6/Stat3 signaling as a function of cellular context mediates Ras-induced transformation
INTRODUCTION: Tyrosine phosphorylated signal transducer and activator of transcription 3 (pStat3) is expressed in numerous cancers and is required for mediating tumorigenesis. Autocrine and paracrine interleukin (IL)-6 signaling is the principal mechanism by which Stat3 is persistently phosphorylate...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3096973/ https://ncbi.nlm.nih.gov/pubmed/20929542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2725 |
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