Differential interleukin-6/Stat3 signaling as a function of cellular context mediates Ras-induced transformation

INTRODUCTION: Tyrosine phosphorylated signal transducer and activator of transcription 3 (pStat3) is expressed in numerous cancers and is required for mediating tumorigenesis. Autocrine and paracrine interleukin (IL)-6 signaling is the principal mechanism by which Stat3 is persistently phosphorylate...

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Main Authors: Leslie, Kenneth, Gao, Sizhi P, Berishaj, Marjan, Podsypanina, Katrina, Ho, Hao, Ivashkiv, Lionel, Bromberg, Jacqueline
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096973/
https://ncbi.nlm.nih.gov/pubmed/20929542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2725
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