The IL-6/JAK/Stat3 Feed-Forward Loop Drives Tumorigenesis and Metastasis

We have investigated the importance of interleukin-6 (IL-6) in promoting tumor growth and metastasis. In human primary breast cancers, increased levels of IL-6 were found at the tumor leading edge and positively correlated with advanced stage, suggesting a mechanistic link between tumor cell product...

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Autors principals: Chang, Qing, Bournazou, Eirini, Sansone, Pasquale, Berishaj, Marjan, Gao, Sizhi Paul, Daly, Laura, Wels, Jared, Theilen, Till, Granitto, Selena, Zhang, Xinmin, Cotari, Jesse, Alpaugh, Mary L, de Stanchina, Elisa, Manova, Katia, Li, Ming, Bonafe, Massimiliano, Ceccarelli, Claudio, Taffurelli, Mario, Santini, Donatella, Altan-Bonnet, Gregoire, Kaplan, Rosandra, Norton, Larry, Nishimoto, Norihiro, Huszar, Dennis, Lyden, David, Bromberg, Jacqueline
Format: Artigo
Idioma:Inglês
Publicat: Neoplasia Press Inc. 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689247/
https://ncbi.nlm.nih.gov/pubmed/23814496
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