Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts In Vitro Antimalarial Activity

Por Giannangelo, Carlo, Stingelin, Lukas, Yang, Tuo, Tilley, Leann, Charman, Susan A., Creek, Darren J.
Publicado no Antimicrob Agents Chemother (2018)

Biopharmaceutical characterisation of a low-dose (75 mg) controlled-release aspirin formulation.

Por Charman, W N, Charman, S A, Monkhouse, D C, Frisbee, S E, Lockhart, E A, Weisman, S, Fitzgerald, G A
Publicado em 1993

Subunit interactions change the heme active-site geometry in p-cresol methylhydroxylase.

Por McLendon, G L, Bagby, S, Charman, J A, Driscoll, P C, McIntire, W S, Mathews, F S, Hill, H A
Publicado em 1991

Comparative Antimalarial Activities of Six Pairs of 1,2,4,5-Tetraoxanes (Peroxide Dimers) and 1,2,4,5,7,8-Hexaoxonanes (Peroxide Trimers)

Por Dong, Yuxiang, Creek, Darren, Chollet, Jacques, Matile, Hugues, Charman, Susan A., Wittlin, Sergio, Wood, James K., Vennerstrom, Jonathan L.
Publicado em 2007

System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion

Por Giannangelo, Carlo, Siddiqui, Ghizal, De Paoli, Amanda, Anderson, Bethany M., Edgington-Mitchell, Laura E., Charman, Susan A., Creek, Darren J.
Publicado no PLoS Pathog (2020)

Relationship between Antimalarial Activity and Heme Alkylation for Spiro- and Dispiro-1,2,4-Trioxolane Antimalarials

Por Creek, Darren J., Charman, William N., Chiu, Francis C. K., Prankerd, Richard J., Dong, Yuxiang, Vennerstrom, Jonathan L., Charman, Susan A.
Publicado em 2008

Stability of Peroxide Antimalarials in the Presence of Human Hemoglobin

Por Creek, Darren J., Ryan, Eileen, Charman, William N., Chiu, Francis C. K., Prankerd, Richard J., Vennerstrom, Jonathan L., Charman, Susan A.
Publicado em 2009

Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strain...

Por Yang, Tuo, Xie, Stanley C., Cao, Pengxing, Giannangelo, Carlo, McCaw, James, Creek, Darren J., Charman, Susan A., Klonis, Nectarios, Tilley, Leann
Publicado no Antimicrob Agents Chemother (2016)

Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparu...

Por Marwaha, Alka, White, John, El_Mazouni, Farah, Creason, Sharon A, Kokkonda, Sreekanth, Buckner, Frederick S., Charman, Susan A., Phillips, Margaret A., Rathod, Pradipsinh K.
Publicado em 2012

Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria

Por Lauterwasser, Erica M. W., Fontaine, Shaun D., Li, Hao, Gut, Jiri, Katneni, Kasiram, Charman, Susan A., Rosenthal, Philip J., Bogyo, Matthew, Renslo, Adam R.
Publicado no ACS Med Chem Lett (2015)

SAR of a New Antischistosomal Urea Carboxylic Acid

Por Wu, Jianbo, Wang, Chunkai, Häberli, Cécile, White, Karen L., Shackleford, David M., Chen, Gong, Dong, Yuxiang, Charman, Susan A., Keiser, Jennifer, Vennerstrom, Jonathan L.
Publicado no Bioorg Med Chem Lett (2018)

Discovery and Structure–Activity Relationships of Pyrrolone Antimalarials

Por Murugesan, Dinakaran, Mital, Alka, Kaiser, Marcel, Shackleford, David M., Morizzi, Julia, Katneni, Kasiram, Campbell, Michael, Hudson, Alan, Charman, Susan A., Yeates, Clive, Gilbert, Ian H.
Publicado em 2013

Structure–Activity Relationship Studies of Pyrrolone Antimalarial Agents

Por Murugesan, Dinakaran, Kaiser, Marcel, White, Karen L, Norval, Suzanne, Riley, Jennifer, Wyatt, Paul G, Charman, Susan A, Read, Kevin D, Yeates, Clive, Gilbert, Ian H
Publicado em 2013

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

Por Deng, Xiaoyi, Kokkonda, Sreekanth, El Mazouni, Farah, White, John, Burrows, Jeremy N., Kaminsky, Werner, Charman, Susan A., Matthews, David, Rathod, Pradipsinh K., Phillips, Margaret A.
Publicado em 2014

Development of Diaminoquinazoline Histone Lysine Methyltransferase Inhibitors as Potent Blood-stage Anti-Malarial Compounds

Por Sundriyal, Sandeep, Malmquist, Nicholas A., Caron, Joachim, Blundell, Scott, Liu, Feng, Chen, Xin, Srimongkolpithak, Nitipol, Jin, Jian, Charman, Susan A., Scherf, Artur, Fuchter, Matthew J.
Publicado em 2014

Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds

Por Katneni, Kasiram, Pham, Thao, Saunders, Jessica, Chen, Gong, Patil, Rahul, White, Karen L., Abla, Nada, Chiu, Francis C. K., Shackleford, David M., Charman, Susan A.
Publicado no Pharm Res (2018)

Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development

Por Zaloumis, Sophie, Humberstone, Andrew, Charman, Susan A, Price, Ric N, Moehrle, Joerg, Gamo-Benito, Javier, McCaw, James, Jamsen, Kris M, Smith, Katherine, Simpson, Julie A
Publicado em 2012

Inhibition of Cytomegalovirus Replication with Extended-Half-Life Synthetic Ozonides

Por Wang, Yiping, Mukhopadhyay, Rupkatha, Roy, Sujayita, Kapoor, Arun, Su, Yu-Pin, Charman, Susan A., Chen, Gong, Wu, Jianbo, Wang, Xiaofang, Vennerstrom, Jonathan L., Arav-Boger, Ravit
Publicado no Antimicrob Agents Chemother (2018)

First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials

Por Moehrle, Joerg J, Duparc, Stephan, Siethoff, Christoph, Giersbergen, Paul L M, Craft, J Carl, Arbe-Barnes, Sarah, Charman, Susan A, Gutierrez, Maria, Wittlin, Sergio, Vennerstrom, Jonathan L
Publicado em 2013

Complexes of Trypanosoma cruzi Sterol 14α-Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITY

Por Hargrove, Tatiana Y., Wawrzak, Zdzislaw, Alexander, Paul W., Chaplin, Jason H., Keenan, Martine, Charman, Susan A., Perez, Catherine J., Waterman, Michael R., Chatelain, Eric, Lepesheva, Galina I.
Publicado em 2013