System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion

Ozonide antimalarials, OZ277 (arterolane) and OZ439 (artefenomel), are synthetic peroxide-based antimalarials with potent activity against the deadliest malaria parasite, Plasmodium falciparum. Here we used a “multi-omics” workflow, in combination with activity-based protein profiling (ABPP), to dem...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Giannangelo, Carlo, Siddiqui, Ghizal, De Paoli, Amanda, Anderson, Bethany M., Edgington-Mitchell, Laura E., Charman, Susan A., Creek, Darren J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7347234/
https://ncbi.nlm.nih.gov/pubmed/32589689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008485
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