SAR of a New Antischistosomal Urea Carboxylic Acid

Urea carboxylic acids, products of aryl hydantoin hydrolysis, were recently identified as a new antischistosomal chemotype. We now describe a baseline structure-activity relationship (SAR) for this compound series. With one exception, analogs of lead urea carboxylic acid 2 were quite polar with LogD...

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Detaylı Bibliyografya
Yayımlandı:Bioorg Med Chem Lett
Asıl Yazarlar: Wu, Jianbo, Wang, Chunkai, Häberli, Cécile, White, Karen L., Shackleford, David M., Chen, Gong, Dong, Yuxiang, Charman, Susan A., Keiser, Jennifer, Vennerstrom, Jonathan L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6301076/
https://ncbi.nlm.nih.gov/pubmed/30389288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.10.039
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