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Antischistosomal versus Antiandrogenic Properties of Aryl Hydantoin Ro 13-3978
In the early 1980s, the antischistosomal aryl hydantoin Ro 13-3978 (AH01), a close structural analogue of the androgen receptor antagonist nilutamide, was discovered. Administration of 100 mg/kg oral doses of AH01 to mice infected with adult and juvenile Schistosoma mansoni produced 95% and 64% tota...
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| Autores principales: | , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The American Society of Tropical Medicine and Hygiene
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4047746/ https://ncbi.nlm.nih.gov/pubmed/24686741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4269/ajtmh.14-0029 |
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