Revisiting the SAR of the Antischistosomal Aryl Hydantoin (Ro 13-3978)

[Image: see text] The aryl hydantoin 1 (Ro 13-3978) was identified in the early 1980s as a promising antischistosomal lead compound. However, this series of aryl hydantoins produced antiandrogenic side effects in the host, a not unexpected outcome given their close structural similarity to the antia...

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Julkaisussa:J Med Chem
Päätekijät: Wang, Chunkai, Zhao, Qingjie, Vargas, Mireille, Jones, Jeremy O., White, Karen L., Shackleford, David M., Chen, Gong, Saunders, Jessica, Ng, Alice C. F., Chiu, Francis C. K., Dong, Yuxiang, Charman, Susan A., Keiser, Jennifer, Vennerstrom, Jonathan L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2016
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150661/
https://ncbi.nlm.nih.gov/pubmed/27933964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01410
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