Revisiting the SAR of the Antischistosomal Aryl Hydantoin (Ro 13-3978)

[Image: see text] The aryl hydantoin 1 (Ro 13-3978) was identified in the early 1980s as a promising antischistosomal lead compound. However, this series of aryl hydantoins produced antiandrogenic side effects in the host, a not unexpected outcome given their close structural similarity to the antia...

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Detaylı Bibliyografya
Yayımlandı:J Med Chem
Asıl Yazarlar: Wang, Chunkai, Zhao, Qingjie, Vargas, Mireille, Jones, Jeremy O., White, Karen L., Shackleford, David M., Chen, Gong, Saunders, Jessica, Ng, Alice C. F., Chiu, Francis C. K., Dong, Yuxiang, Charman, Susan A., Keiser, Jennifer, Vennerstrom, Jonathan L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2016
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150661/
https://ncbi.nlm.nih.gov/pubmed/27933964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01410
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