Progress in Antischistosomal N,N′-Diarylurea SAR

N,N ′-diarylureas have recently emerged as a new antischistosomal chemotype. We now describe physicochemical profiling, in vitro ADME, plasma exposure, and ex vivo and in vivo activities against Schistosoma mansoni for twenty new N,N′-diarylureas designed primarily to increase aqueous solubility, bu...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem Lett
Main Authors: Wu, Jianbo, Wang, Chunkai, Leas, Derek, Vargas, Mireille, White, Karen L., Shackleford, David M., Chen, Gong, Sanford, Austin G., Hemsley, Ryan M., Davis, Paul H., Dong, Yuxiang, Charman, Susan A., Keiser, Jennifer, Vennerstrom, Jonathan L.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026081/
https://ncbi.nlm.nih.gov/pubmed/29317164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.12.064
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