Antischistosomal versus Antiandrogenic Properties of Aryl Hydantoin Ro 13-3978

In the early 1980s, the antischistosomal aryl hydantoin Ro 13-3978 (AH01), a close structural analogue of the androgen receptor antagonist nilutamide, was discovered. Administration of 100 mg/kg oral doses of AH01 to mice infected with adult and juvenile Schistosoma mansoni produced 95% and 64% tota...

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Main Authors: Wang, Chunkai, Zhao, Qingjie, Min, Jaeki, Muniyan, Sakthivel, Vargas, Mireille, Wang, Xiaofang, Dong, Yuxiang, Guy, R. Kiplin, Lin, Ming-Fong, Keiser, Jennifer, Vennerstrom, Jonathan L.
Format: Artigo
Jezik:Inglês
Izdano: The American Society of Tropical Medicine and Hygiene 2014
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047746/
https://ncbi.nlm.nih.gov/pubmed/24686741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4269/ajtmh.14-0029
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