SAR of a New Antischistosomal Urea Carboxylic Acid

Urea carboxylic acids, products of aryl hydantoin hydrolysis, were recently identified as a new antischistosomal chemotype. We now describe a baseline structure-activity relationship (SAR) for this compound series. With one exception, analogs of lead urea carboxylic acid 2 were quite polar with LogD...

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發表在:Bioorg Med Chem Lett
Main Authors: Wu, Jianbo, Wang, Chunkai, Häberli, Cécile, White, Karen L., Shackleford, David M., Chen, Gong, Dong, Yuxiang, Charman, Susan A., Keiser, Jennifer, Vennerstrom, Jonathan L.
格式: Artigo
語言:Inglês
出版: 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6301076/
https://ncbi.nlm.nih.gov/pubmed/30389288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.10.039
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