Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts In Vitro Antimalarial Activity

著者: Giannangelo, Carlo, Stingelin, Lukas, Yang, Tuo, Tilley, Leann, Charman, Susan A., Creek, Darren J.
出版年 Antimicrob Agents Chemother (2018)

Biopharmaceutical characterisation of a low-dose (75 mg) controlled-release aspirin formulation.

著者: Charman, W N, Charman, S A, Monkhouse, D C, Frisbee, S E, Lockhart, E A, Weisman, S, Fitzgerald, G A
出版事項 1993

Subunit interactions change the heme active-site geometry in p-cresol methylhydroxylase.

著者: McLendon, G L, Bagby, S, Charman, J A, Driscoll, P C, McIntire, W S, Mathews, F S, Hill, H A
出版事項 1991

Comparative Antimalarial Activities of Six Pairs of 1,2,4,5-Tetraoxanes (Peroxide Dimers) and 1,2,4,5,7,8-Hexaoxonanes (Peroxide Trimers)

著者: Dong, Yuxiang, Creek, Darren, Chollet, Jacques, Matile, Hugues, Charman, Susan A., Wittlin, Sergio, Wood, James K., Vennerstrom, Jonathan L.
出版事項 2007

System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion

著者: Giannangelo, Carlo, Siddiqui, Ghizal, De Paoli, Amanda, Anderson, Bethany M., Edgington-Mitchell, Laura E., Charman, Susan A., Creek, Darren J.
出版年 PLoS Pathog (2020)

Relationship between Antimalarial Activity and Heme Alkylation for Spiro- and Dispiro-1,2,4-Trioxolane Antimalarials

著者: Creek, Darren J., Charman, William N., Chiu, Francis C. K., Prankerd, Richard J., Dong, Yuxiang, Vennerstrom, Jonathan L., Charman, Susan A.
出版事項 2008

Stability of Peroxide Antimalarials in the Presence of Human Hemoglobin

著者: Creek, Darren J., Ryan, Eileen, Charman, William N., Chiu, Francis C. K., Prankerd, Richard J., Vennerstrom, Jonathan L., Charman, Susan A.
出版事項 2009

Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strain...

著者: Yang, Tuo, Xie, Stanley C., Cao, Pengxing, Giannangelo, Carlo, McCaw, James, Creek, Darren J., Charman, Susan A., Klonis, Nectarios, Tilley, Leann
出版年 Antimicrob Agents Chemother (2016)

Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparu...

著者: Marwaha, Alka, White, John, El_Mazouni, Farah, Creason, Sharon A, Kokkonda, Sreekanth, Buckner, Frederick S., Charman, Susan A., Phillips, Margaret A., Rathod, Pradipsinh K.
出版事項 2012

Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria

著者: Lauterwasser, Erica M. W., Fontaine, Shaun D., Li, Hao, Gut, Jiri, Katneni, Kasiram, Charman, Susan A., Rosenthal, Philip J., Bogyo, Matthew, Renslo, Adam R.
出版年 ACS Med Chem Lett (2015)

SAR of a New Antischistosomal Urea Carboxylic Acid

著者: Wu, Jianbo, Wang, Chunkai, Häberli, Cécile, White, Karen L., Shackleford, David M., Chen, Gong, Dong, Yuxiang, Charman, Susan A., Keiser, Jennifer, Vennerstrom, Jonathan L.
出版年 Bioorg Med Chem Lett (2018)

Discovery and Structure–Activity Relationships of Pyrrolone Antimalarials

著者: Murugesan, Dinakaran, Mital, Alka, Kaiser, Marcel, Shackleford, David M., Morizzi, Julia, Katneni, Kasiram, Campbell, Michael, Hudson, Alan, Charman, Susan A., Yeates, Clive, Gilbert, Ian H.
出版事項 2013

Structure–Activity Relationship Studies of Pyrrolone Antimalarial Agents

著者: Murugesan, Dinakaran, Kaiser, Marcel, White, Karen L, Norval, Suzanne, Riley, Jennifer, Wyatt, Paul G, Charman, Susan A, Read, Kevin D, Yeates, Clive, Gilbert, Ian H
出版事項 2013

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

著者: Deng, Xiaoyi, Kokkonda, Sreekanth, El Mazouni, Farah, White, John, Burrows, Jeremy N., Kaminsky, Werner, Charman, Susan A., Matthews, David, Rathod, Pradipsinh K., Phillips, Margaret A.
出版事項 2014

Development of Diaminoquinazoline Histone Lysine Methyltransferase Inhibitors as Potent Blood-stage Anti-Malarial Compounds

著者: Sundriyal, Sandeep, Malmquist, Nicholas A., Caron, Joachim, Blundell, Scott, Liu, Feng, Chen, Xin, Srimongkolpithak, Nitipol, Jin, Jian, Charman, Susan A., Scherf, Artur, Fuchter, Matthew J.
出版事項 2014

Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds

著者: Katneni, Kasiram, Pham, Thao, Saunders, Jessica, Chen, Gong, Patil, Rahul, White, Karen L., Abla, Nada, Chiu, Francis C. K., Shackleford, David M., Charman, Susan A.
出版年 Pharm Res (2018)

Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development

著者: Zaloumis, Sophie, Humberstone, Andrew, Charman, Susan A, Price, Ric N, Moehrle, Joerg, Gamo-Benito, Javier, McCaw, James, Jamsen, Kris M, Smith, Katherine, Simpson, Julie A
出版事項 2012

Inhibition of Cytomegalovirus Replication with Extended-Half-Life Synthetic Ozonides

著者: Wang, Yiping, Mukhopadhyay, Rupkatha, Roy, Sujayita, Kapoor, Arun, Su, Yu-Pin, Charman, Susan A., Chen, Gong, Wu, Jianbo, Wang, Xiaofang, Vennerstrom, Jonathan L., Arav-Boger, Ravit
出版年 Antimicrob Agents Chemother (2018)

First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials

著者: Moehrle, Joerg J, Duparc, Stephan, Siethoff, Christoph, Giersbergen, Paul L M, Craft, J Carl, Arbe-Barnes, Sarah, Charman, Susan A, Gutierrez, Maria, Wittlin, Sergio, Vennerstrom, Jonathan L
出版事項 2013

Complexes of Trypanosoma cruzi Sterol 14α-Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITY

著者: Hargrove, Tatiana Y., Wawrzak, Zdzislaw, Alexander, Paul W., Chaplin, Jason H., Keenan, Martine, Charman, Susan A., Perez, Catherine J., Waterman, Michael R., Chatelain, Eric, Lepesheva, Galina I.
出版事項 2013