Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds

PURPOSE: To examine the utility of human plasma as an assay medium in Caco-2 permeability studies to overcome poor mass balance and inadequate sink conditions frequently encountered with lipophilic compounds. METHODS: Caco-2 permeability was assessed for reference compounds with known transport mech...

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Detalhes bibliográficos
Publicado no:Pharm Res
Main Authors: Katneni, Kasiram, Pham, Thao, Saunders, Jessica, Chen, Gong, Patil, Rahul, White, Karen L., Abla, Nada, Chiu, Francis C. K., Shackleford, David M., Charman, Susan A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156755/
https://ncbi.nlm.nih.gov/pubmed/30225649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-018-2493-3
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