Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development

BACKGROUND: Mechanistic within-host models relating blood anti-malarial drug concentrations with the parasite-time profile help in assessing dosing schedules and partner drugs for new anti-malarial treatments. A comprehensive simulation study to assess the utility of a stage-specific pharmacokinetic...

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Detalhes bibliográficos
Main Authors: Zaloumis, Sophie, Humberstone, Andrew, Charman, Susan A, Price, Ric N, Moehrle, Joerg, Gamo-Benito, Javier, McCaw, James, Jamsen, Kris M, Smith, Katherine, Simpson, Julie A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Methodology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3546862/
https://ncbi.nlm.nih.gov/pubmed/22931058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-11-303
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