Smaug/SAMD4A Restores Translational Activity of CUGBP1 and Suppresses CUG-Induced Myopathy

Por de Haro, Maria, Al-Ramahi, Ismael, Jones, Karlie R., Holth, Jerrah K., Timchenko, Lubov T., Botas, Juan
Publicado em 2013

TORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich’s Ataxia

Por Calap-Quintana, Pablo, Soriano, Sirena, Llorens, José Vicente, Al-Ramahi, Ismael, Botas, Juan, Moltó, María Dolores, Martínez-Sebastián, María José
Publicado no PLoS One (2015)

Inhibition of Lipid Signaling Enzyme Diacylglycerol Kinase ϵ Attenuates Mutant Huntingtin Toxicity

Por Zhang, Ningzhe, Li, Bensheng, Al-Ramahi, Ismael, Cong, Xin, Held, Jason M., Kim, Eugene, Botas, Juan, Gibson, Bradford W., Ellerby, Lisa M.
Publicado em 2012

Metal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the Disease

Por Soriano, Sirena, Calap-Quintana, Pablo, Llorens, José Vicente, Al-Ramahi, Ismael, Gutiérrez, Lucía, Martínez-Sebastián, María José, Botas, Juan, Moltó, María Dolores
Publicado no PLoS One (2016)

dAtaxin-2 Mediates Expanded Ataxin-1-Induced Neurodegeneration in a Drosophila Model of SCA1

Por Al-Ramahi, Ismael, Pérez, Alma M, Lim, Janghoo, Zhang, Minghang, Sorensen, Rie, de Haro, Maria, Branco, Joana, Pulst, Stefan M, Zoghbi, Huda Y, Botas, Juan
Publicado em 2007

A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity

Por Yao, Yuwei, Cui, Xiaotian, Al-Ramahi, Ismael, Sun, Xiaoli, Li, Bo, Hou, Jiapeng, Difiglia, Marian, Palacino, James, Wu, Zhi-Ying, Ma, Lixiang, Botas, Juan, Lu, Boxun
Publicado no eLife (2015)

Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

Por Shirasaki, Dyna I., Greiner, Erin R., Al-Ramahi, Ismael, Gray, Michelle, Boontheung, Pinmanee, Geschwind, Daniel H., Botas, Juan, Coppola, Giovanni, Horvath, Steve, Loo, Joseph A., Yang, X. William
Publicado em 2012

Matrix Metalloproteinases are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington’s Disease

Por Miller, John P., Holcomb, Jennifer, Al-Ramahi, Ismael, de Haro, Maria, Gafni, Juliette, Zhang, Ningzhe, Kim, Eugene, Sanhueza, Mario, Torcassi, Cameron, Kwak, Seung, Botas, Juan, Hughes, Robert E., Ellerby, Lisa M.
Publicado em 2010

Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation

Por El-Daher, Marie-Thérèse, Hangen, Emilie, Bruyère, Julie, Poizat, Ghislaine, Al-Ramahi, Ismael, Pardo, Raul, Bourg, Nicolas, Souquere, Sylvie, Mayet, Céline, Pierron, Gérard, Lévêque-Fort, Sandrine, Botas, Juan, Humbert, Sandrine, Saudou, Frédéric
Publicado no EMBO J (2015)

Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease

Por Huichalaf, Claudia H, Al-Ramahi, Ismael, Park, Kyung-Won, Grunke, Stacy D, Lu, Nan, de Haro, Maria, El-Zein, Karla, Gallego-Flores, Tatiana, Perez, Alma M, Jung, Sung Yun, Botas, Juan, Zoghbi, Huda Y, Jankowsky, Joanna L
Publicado no Hum Mol Genet (2019)

A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease

Por Miller, John P., Yates, Bridget E., Al-Ramahi, Ismael, Berman, Ari E., Sanhueza, Mario, Kim, Eugene, de Haro, Maria, DeGiacomo, Francesco, Torcassi, Cameron, Holcomb, Jennifer, Gafni, Juliette, Mooney, Sean D., Botas, Juan, Ellerby, Lisa M., Hughes, Robert E.
Publicado em 2012

TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau

Por Rousseaux, Maxime WC, de Haro, Maria, Lasagna-Reeves, Cristian A, De Maio, Antonia, Park, Jeehye, Jafar-Nejad, Paymaan, Al-Ramahi, Ismael, Sharma, Ajay, See, Lauren, Lu, Nan, Vilanova-Velez, Luis, Klisch, Tiemo J, Westbrook, Thomas F, Troncoso, Juan C, Botas, Juan, Zoghbi, Huda Y
Publicado no eLife (2016)

Reduction of Nuak1 decreases tau and reverses phenotypes in a tauopathy mouse model

Por Lasagna-Reeves, Cristian A., de Haro, Maria, Hao, Shuang, Park, Jeehye, Rousseaux, Maxime W.C., Al-Ramahi, Ismael, Jafar-Nejad, Paymaan, Vilanova-Velez, Luis, See, Lauren, De Maio, Antonia, Nitschke, Larissa, Wu, Zhenyu, Troncoso, Juan C., Westbrook, Thomas F., Tang, Jianrong, Botas, Juan, Zoghbi, Huda.Y.
Publicado no Neuron (2016)

Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein

Por Al-Ramahi, Ismael, Giridharan, Sai Srinivas Panapakkam, Chen, Yu-Chi, Patnaik, Samarjit, Safren, Nathaniel, Hasegawa, Junya, de Haro, Maria, Wagner Gee, Amanda K, Titus, Steven A, Jeong, Hyunkyung, Clarke, Jonathan, Krainc, Dimitri, Zheng, Wei, Irvine, Robin F, Barmada, Sami, Ferrer, Marc, Southall, Noel, Weisman, Lois S, Botas, Juan, Marugan, Juan Jose
Publicado no eLife (2017)

Integrated genomics and proteomics to define huntingtin CAG length-dependent networks in HD Mice

Por Langfelder, Peter, Cantle, Jeffrey P., Chatzopoulou, Doxa, Wang, Nan, Gao, Fuying, Al-Ramahi, Ismael, Lu, Xiao-Hong, Ramos, Eliana Marisa, El-Zein, Karla, Zhao, Yining, Deverasetty, Sandeep, Tebbe, Andreas, Schaab, Christoph, Lavery, Daniel J., Howland, David, Kwak, Seung, Botas, Juan, Aaronson, Jeffrey S., Rosinski, Jim, Coppola, Giovanni, Horvath, Steve, Yang, X. William
Publicado no Nat Neurosci (2016)

High-throughput functional analysis distinguishes pathogenic, nonpathogenic, and compensatory transcriptional changes in a neurodegenerative disorder

Por Al-Ramahi, Ismael, Lu, Boxun, Di Paola, Simone, Pang, Kaifang, de Haro, Maria, Peluso, Ivana, Gallego-Flores, Tatiana, Malik, Nazish T., Erikson, Kelly, Bleiberg, Benjamin A., Avalos, Matthew, Fan, George, Rivers, Laura Elizabeth, Laitman, Andrew M., Diaz-García, Javier R., Hild, Marc, Palacino, James, Liu, Zhandong, Medina, Diego L., Botas, Juan
Publicado no Cell Syst (2018)

Genetic screens reveal RAS/MAPK/MSK1 modulate ataxin 1 protein levels and toxicity in SCA1

Por Park, Jeehye, Al-Ramahi, Ismael, Tan, Qiumin, Mollema, Nissa, Diaz-Garcia, Javier R., Gallego-Flores, Tatiana, Lu, Hsiang-Chih, Lagalwar, Sarita, Duvick, Lisa, Kang, Hyojin, Lee, Yoontae, Jafar-Nejad, Paymaan, Sayegh, Layal S., Richman, Ronald, Liu, Xiuyun, Gao, Yan, Shaw, Chad A., Arthur, J. Simon C., Orr, Harry T., Westbrook, Thomas F., Botas, Juan, Zoghbi, Huda Y.
Publicado em 2013

A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach

Por Rousseaux, Maxime W.C., Vázquez-Vélez, Gabriel E., Al-Ramahi, Ismael, Jeong, Hyun-Hwan, Bajić, Aleksandar, Revelli, Jean-Pierre, Ye, Hui, Phan, Emily T., Deger, Jennifer M., Perez, Alma M., Kim, Ji-Yoen, Lavery, Laura A., Xu, Qikia, Li, Mamie Z., Kang, Hyojin, Kim, Jean J., Shulman, Joshua M., Westbrook, Thomas F., Elledge, Stephen J., Liu, Zhandong, Botas, Juan, Zoghbi, Huda Y.
Publicado no J Neurosci (2018)