Lysosomal calcium regulates autophagy

por Medina, Diego L, Ballabio, Andrea
Publicado en Autophagy (2015)

The rapidly evolving view of lysosomal storage diseases

por Parenti, Giancarlo, Medina, Diego L, Ballabio, Andrea
Publicado en EMBO Mol Med (2021)

Signals for the lysosome: a control center for cellular clearance and energy metabolism

por Settembre, Carmine, Fraldi, Alessandro, Medina, Diego L., Ballabio, Andrea
Publicado en Nat Rev Mol Cell Biol (2013)

Comparing structural and transcriptional drug networks reveals signatures of drug activity and toxicity in transcriptional responses

por Sirci, Francesco, Napolitano, Francesco, Pisonero-Vaquero, Sandra, Carrella, Diego, Medina, Diego L., di Bernardo, Diego
Publicado en NPJ Syst Biol Appl (2017)

A reverse-engineering approach to dissect post-translational modulators of transcription factor’s activity from transcriptional data

por Gambardella, Gennaro, Peluso, Ivana, Montefusco, Sandro, Bansal, Mukesh, Medina, Diego L., Lawrence, Neil, di Bernardo, Diego
Publicado en BMC Bioinformatics (2015)

TrkB regulates neocortex formation through the Shc/PLCγ-mediated control of neuronal migration

por Medina, Diego L, Sciarretta, Carla, Calella, Anna Maria, von Bohlen und Halbach, Oliver, Unsicker, Klaus, Minichiello, Liliana
Publicado 2004

TFEB-mediated increase in peripheral lysosomes regulates store-operated calcium entry

por Sbano, Luigi, Bonora, Massimo, Marchi, Saverio, Baldassari, Federica, Medina, Diego L., Ballabio, Andrea, Giorgi, Carlotta, Pinton, Paolo
Publicado en Sci Rep (2017)

The Phytoestrogen Genistein Modulates Lysosomal Metabolism and Transcription Factor EB (TFEB) Activation

por Moskot, Marta, Montefusco, Sandro, Jakóbkiewicz-Banecka, Joanna, Mozolewski, Paweł, Węgrzyn, Alicja, Di Bernardo, Diego, Węgrzyn, Grzegorz, Medina, Diego L., Ballabio, Andrea, Gabig-Cimińska, Magdalena
Publicado 2014

TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy

por Nnah, Israel C., Wang, Biao, Saqcena, Chaitali, Weber, Gregory F., Bonder, Edward M., Bagley, Dustin, De Cegli, Rossella, Napolitano, Gennaro, Medina, Diego L., Ballabio, Andrea, Dobrowolski, Radek
Publicado en Autophagy (2018)

Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance

por Medina, Diego L., Fraldi, Alessandro, Bouche, Valentina, Annunziata, Fabio, Mansueto, Gelsomina, Spampanato, Carmine, Puri, Claudia, Pignata, Antonella, Martina, Jose A., Sardiello, Marco, Palmieri, Michela, Polishchuk, Roman, Puertollano, Rosa, Ballabio, Andrea
Publicado 2011

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

por Settembre, Carmine, Zoncu, Roberto, Medina, Diego L, Vetrini, Francesco, Erdin, Serkan, Erdin, SerpilUckac, Huynh, Tuong, Ferron, Mathieu, Karsenty, Gerard, Vellard, Michel C, Facchinetti, Valeria, Sabatini, David M, Ballabio, Andrea
Publicado 2012

Autophagy modulator scoring system: a user-friendly tool for quantitative analysis of methodological integrity of chemical autophagy modulator studies

por Dong, Yu, Hu, Yuanjia, Sarkar, Sovan, Zong, Wei-Xing, Li, Min, Feng, Du, Song, Ju-Xian, Li, Min, Medina, Diego L., Tan, Jieqiong, Zhang, Zhuohua, Yue, Zhenyu, Lu, Jia-Hong
Publicado en Autophagy (2019)

SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Interventio...

por Calamita, Piera, Miluzio, Annarita, Russo, Arianna, Pesce, Elisa, Ricciardi, Sara, Khanim, Farhat, Cheroni, Cristina, Alfieri, Roberta, Mancino, Marilena, Gorrini, Chiara, Rossetti, Grazisa, Peluso, Ivana, Pagani, Massimiliano, Medina, Diego L., Rommens, Johanna, Biffo, Stefano
Publicado en PLoS Genet (2017)

The activity of Sac1 across ER–TGN contact sites requires the four-phosphate-adaptor-protein-1

por Venditti, Rossella, Masone, Maria Chiara, Rega, Laura Rita, Di Tullio, Giuseppe, Santoro, Michele, Polishchuk, Elena, Serrano, Ivan Castello, Olkkonen, Vesa M., Harada, Akihiro, Medina, Diego L., La Montagna, Raffaele, De Matteis, Maria Antonietta
Publicado en J Cell Biol (2019)

Automatic identification of small molecules that promote cell conversion and reprogramming

por Napolitano, Francesco, Rapakoulia, Trisevgeni, Annunziata, Patrizia, Hasegawa, Akira, Cardon, Melissa, Napolitano, Sara, Vaccaro, Lorenzo, Iuliano, Antonella, Wanderlingh, Luca Giorgio, Kasukawa, Takeya, Medina, Diego L., Cacchiarelli, Davide, Gao, Xin, di Bernardo, Diego, Arner, Erik
Publicado en Stem Cell Reports (2021)

NF-κB Activity Initiates Human ESC-Derived Neural Progenitor Cell Differentiation by Inducing a Metabolic Maturation Program

por FitzPatrick, Lorna M., Hawkins, Kate E., Delhove, Juliette M.K.M., Fernandez, Emilio, Soldati, Chiara, Bullen, Louise F., Nohturfft, Axel, Waddington, Simon N., Medina, Diego L., Bolaños, Juan P., McKay, Tristan R.
Publicado en Stem Cell Reports (2018)

Synthetic Lethality Screening Identifies FDA-Approved Drugs that Overcome ATP7B-Mediated Tolerance of Tumor Cells to Cisplatin

por Mariniello, Marta, Petruzzelli, Raffaella, Wanderlingh, Luca G., La Montagna, Raffaele, Carissimo, Annamaria, Pane, Francesca, Amoresano, Angela, Ilyechova, Ekaterina Y., Galagudza, Michael M., Catalano, Federico, Crispino, Roberta, Puchkova, Ludmila V., Medina, Diego L., Polishchuk, Roman S.
Publicado en Cancers (Basel) (2020)

Lysosomal calcium signaling regulates autophagy via calcineurin and TFEB

por Medina, Diego L., Di Paola, Simone, Peluso, Ivana, Armani, Andrea, De Stefani, Diego, Venditti, Rossella, Montefusco, Sandro, Scotto-Rosato, Anna, Prezioso, Carolina, Forrester, Alison, Settembre, Carmine, Wang, Wuyang, Gao, Qiong, Xu, Haoxing, Sandri, Marco, Rizzuto, Rosario, De Matteis, Maria Antonietta, Ballabio, Andrea
Publicado en Nat Cell Biol (2015)

Fingolimod phosphate inhibits astrocyte inflammatory activity in mucolipidosis IV

por Weinstock, Laura D, Furness, Amanda M, Herron, Shawn S, Smith, Sierra S, Sankar, Sitara B, DeRosa, Samantha G, Gao, Dadi, Mepyans, Molly E, Scotto Rosato, Anna, Medina, Diego L, Vardi, Ayelet, Ferreira, Natalia S, Cho, Soo Min, Futerman, Anthony H, Slaugenhaupt, Susan A, Wood, Levi B, Grishchuk, Yulia
Publicado en Hum Mol Genet (2018)

Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL

por De Leo, Maria Giovanna, Staiano, Leopoldo, Vicinanza, Mariella, Luciani, Alessandro, Carissimo, Annamaria, Mutarelli, Margherita, Di Campli, Antonella, Polishchuk, Elena, Di Tullio, Giuseppe, Morra, Valentina, Levtchenko, Elena, Oltrabella, Francesca, Starborg, Tobias, Santoro, Michele, Di Bernardo, Diego, Devuyst, Olivier, Lowe, Martin, Medina, Diego L., Ballabio, Andrea, De Matteis, Maria Antonietta
Publicado en Nat Cell Biol (2016)