Lysosomal calcium signaling regulates autophagy via calcineurin and TFEB

The view of the lysosome as the terminal end of cellular catabolic pathways has been challenged by recent studies showing a central role of this organelle in the control of cell function. Here we show that a lysosomal Ca(2+) signaling mechanism controls the activities of the phosphatase calcineurin...

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Détails bibliographiques
Publié dans:Nat Cell Biol
Auteurs principaux: Medina, Diego L., Di Paola, Simone, Peluso, Ivana, Armani, Andrea, De Stefani, Diego, Venditti, Rossella, Montefusco, Sandro, Scotto-Rosato, Anna, Prezioso, Carolina, Forrester, Alison, Settembre, Carmine, Wang, Wuyang, Gao, Qiong, Xu, Haoxing, Sandri, Marco, Rizzuto, Rosario, De Matteis, Maria Antonietta, Ballabio, Andrea
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801004/
https://ncbi.nlm.nih.gov/pubmed/25720963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3114
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