The Phytoestrogen Genistein Modulates Lysosomal Metabolism and Transcription Factor EB (TFEB) Activation

Genistein (5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) has been previously proposed as a potential drug for use in substrate reduction therapy for mucopolysaccharidoses, a group of inherited metabolic diseases caused by mutations leading to inefficient degradation of glycosaminoglycans...

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Bibliografiske detaljer
Main Authors: Moskot, Marta, Montefusco, Sandro, Jakóbkiewicz-Banecka, Joanna, Mozolewski, Paweł, Węgrzyn, Alicja, Di Bernardo, Diego, Węgrzyn, Grzegorz, Medina, Diego L., Ballabio, Andrea, Gabig-Cimińska, Magdalena
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059147/
https://ncbi.nlm.nih.gov/pubmed/24770416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.555300
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