Fingolimod phosphate inhibits astrocyte inflammatory activity in mucolipidosis IV

Mucolipidosis IV (MLIV) is an orphan neurodevelopmental disease that causes severe neurologic dysfunction and loss of vision. Currently there is no therapy for MLIV. It is caused by loss of function of the lysosomal channel mucolipin-1, also known as TRPML1. Knockout of the Mcoln1 gene in a mouse mo...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Weinstock, Laura D, Furness, Amanda M, Herron, Shawn S, Smith, Sierra S, Sankar, Sitara B, DeRosa, Samantha G, Gao, Dadi, Mepyans, Molly E, Scotto Rosato, Anna, Medina, Diego L, Vardi, Ayelet, Ferreira, Natalia S, Cho, Soo Min, Futerman, Anthony H, Slaugenhaupt, Susan A, Wood, Levi B, Grishchuk, Yulia
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6915831/
https://ncbi.nlm.nih.gov/pubmed/29771310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy182
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