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Comparing structural and transcriptional drug networks reveals signatures of drug activity and toxicity in transcriptional responses
We performed an integrated analysis of drug chemical structures and drug-induced transcriptional responses. We demonstrated that a network representing three-dimensional structural similarities among 5452 compounds can be used to automatically group together drugs with similar scaffolds, physicochem...
Tallennettuna:
| Julkaisussa: | NPJ Syst Biol Appl |
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| Päätekijät: | , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Nature Publishing Group UK
2017
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5572457/ https://ncbi.nlm.nih.gov/pubmed/28861278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41540-017-0022-3 |
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