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Data mining reveals a network of early-response genes as a consensus signature of drug-induced in vitro and in vivo toxicity

Gene signatures of drug-induced toxicity are of broad interest, but they are often identified from small-scale, single-time point experiments, and are therefore of limited applicability. To address this issue, we performed multivariate analysis of gene expression, cell-based assays, and histopatholo...

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Bibliographic Details
Main Authors: Zhang, J D, Berntenis, N, Roth, A, Ebeling, M
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034126/
https://ncbi.nlm.nih.gov/pubmed/24217556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2013.39
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