Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients

Understanding central mechanisms underlying drug-induced toxicity plays a crucial role in drug development and drug safety. However, a translation of cellular in vitro findings to an actual in vivo context remains challenging. Here, physiologically based pharmacokinetic (PBPK) modeling was used for...

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Bibliographische Detailangaben
Veröffentlicht in:Arch Toxicol
Hauptverfasser: Thiel, Christoph, Cordes, Henrik, Conde, Isabel, Castell, José Vicente, Blank, Lars Mathias, Kuepfer, Lars
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2016
Schlagworte:
In vitro Systems
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5306109/
https://ncbi.nlm.nih.gov/pubmed/27161439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1723-x
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