A Physiology-Based Model of Human Bile Acid Metabolism for Predicting Bile Acid Tissue Levels After Drug Administration in Healthy Subjects and BRIC Type 2 Patients

Drug-induced liver injury (DILI) is a matter of concern in the course of drug development and patient safety, often leading to discontinuation of drug-development programs or early withdrawal of drugs from market. Hepatocellular toxicity or impairment of bile acid (BA) metabolism, known as cholestas...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Baier, Vanessa, Cordes, Henrik, Thiel, Christoph, Castell, José V., Neumann, Ulf P., Blank, Lars M., Kuepfer, Lars
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6777137/
https://ncbi.nlm.nih.gov/pubmed/31611804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.01192
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