Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

We used affinity-purification mass spectrometry to identify 747 candidate proteins that are complexed with Huntingtin (Htt) in distinct brain regions and ages in Huntington’s disease (HD) and wildtype mouse brains. To gain a systems-level view of the Htt interactome, we applied Weighted Gene Correla...

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Detalhes bibliográficos
Main Authors: Shirasaki, Dyna I., Greiner, Erin R., Al-Ramahi, Ismael, Gray, Michelle, Boontheung, Pinmanee, Geschwind, Daniel H., Botas, Juan, Coppola, Giovanni, Horvath, Steve, Loo, Joseph A., Yang, X. William
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432264/
https://ncbi.nlm.nih.gov/pubmed/22794259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.05.024
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