Neuronal Targets of Mutant Huntingtin Genetic Reduction to Ameliorate Huntington’s Disease Pathogenesis in Mice

Huntington’s disease (HD) is a fatal dominantly inherited neurodegenerative disorder caused by a CAG repeat expansion leading to an elongated polyglutamine stretch in Huntingtin(1). Mutant Huntingtin (mHTT) is ubiquitously expressed but elicits selective cortical and striatal neurodegeneration in HD...

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Hlavní autoři: Wang, Nan, Gray, Michelle, Lu, Xiao-Hong, Cantle, Jeffrey P., Holley, Sandra M., Greiner, Erin, Gu, Xiaofeng, Shirasaki, Dyna, Cepeda, Carlos, Li, Yuqing, Dong, Hongwei, Levine, Michael S., Yang, X. William
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067603/
https://ncbi.nlm.nih.gov/pubmed/24784230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3514
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