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Mutant huntingtin reduction in astrocytes slows disease progression in the BACHD conditional Huntington’s disease mouse model
Neuronal and non-neuronal cells express the huntingtin (HTT) protein, yet neurodegeneration in Huntington’s disease (HD) is largely selective, affecting most prominently striatal medium spiny neurons and cortical pyramidal neurons. Selective toxicity of full-length human mutant HTT (fl-mHTT) may be...
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| Publicado no: | Hum Mol Genet |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6337698/ https://ncbi.nlm.nih.gov/pubmed/30312396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy363 |
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