Serines 13 and 16 Are Critical Determinants of Full-length Human Mutant Huntingtin-Induced Disease Pathogenesis in HD Mice

The N-terminal 17-amino-acids of huntingtin (NT17) can be phosphorylated on serines 13 and 16; however, the significance of these modifications in Huntington’s disease pathogenesis remains unknown. In this study, we developed BAC transgenic mice expressing full-length mutant huntingtin (fl-mhtt) wit...

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Detalhes bibliográficos
Main Authors: Gu, Xiaofeng, Greiner, Erin R., Mishra, Rakesh, Kodali, Ravindra, Osmand, Alex, Finkbeiner, Steven, Steffan, Joan S., Thompson, Leslie Michels, Wetzel, Ronald, Yang, X. William
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807408/
https://ncbi.nlm.nih.gov/pubmed/20064390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2009.11.020
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