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Kinetically competing huntingtin aggregation pathways control amyloid polymorphism and properties
In polyglutamine (polyQ) containing fragments of the Huntington’s disease protein huntingtin (htt), the N-terminal 17 amino acid htt(NT) segment serves as the core of α-helical oligomers whose reversible assembly locally concentrates the polyQ segments, thereby facilitating polyQ amyloid nucleation....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3394396/ https://ncbi.nlm.nih.gov/pubmed/22432740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3000929 |
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