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The aggregation-enhancing Huntingtin N-terminus is helical in amyloid fibrils
The 17-residue N-terminus (htt(NT)) directly flanking the polyQ sequence in huntingtin (htt) N-terminal fragments plays a crucial role in initiating and accelerating the aggregation process that is associated with Huntington’s disease (HD) pathogenesis. Here we report on magic-angle-spinning solid s...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3109494/ https://ncbi.nlm.nih.gov/pubmed/21381744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja110715f |
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