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The impact of ataxin-1-like histidine insertions on polyglutamine aggregation
Spinocerebellar ataxia type 1 (SCA1) is one of a group of nine expanded CAG repeat diseases, in which polyglutamine (polyQ) expansion above a threshold is associated with increased disease risk and aggregation. SCA1 is unique in which the polyQ in the disease protein, ataxin1, often contains a few H...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2719497/ https://ncbi.nlm.nih.gov/pubmed/19541676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzp023 |
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