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Mutational analysis of the structural organization of polyglutamine aggregates
The formation of amyloid-like aggregates by expanded polyglutamine (polyGln) sequences is suspected to play a critical role in the neuropathology of Huntington's disease and other expanded CAG-repeat diseases. To probe the folding of the polyGln sequence in the aggregate, we replaced Gln–Gln pa...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC139261/ https://ncbi.nlm.nih.gov/pubmed/12444250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.252523899 |
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