Normal-repeat-length polyglutamine peptides accelerate aggregation nucleation and cytotoxicity of expanded polyglutamine proteins

The dependence of disease risk and age-of-onset on expanded CAG repeat length in diseases like Huntington's disease (HD) is well established and correlates with the repeat-length-dependent nucleation kinetics of polyglutamine (polyGln) aggregation. The wide variation in ages of onset among pati...

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Detalhes bibliográficos
Main Authors: Slepko, Natalia, Bhattacharyya, Anusri M., Jackson, George R., Steffan, Joan S., Marsh, J. Lawrence, Thompson, Leslie Michels, Wetzel, Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1599969/
https://ncbi.nlm.nih.gov/pubmed/16980414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602348103
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