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Assays for studying nucleated aggregation of polyglutamine proteins

The aggregation of polyglutamine containing protein sequences is implicated in a family of familial neurodegenerative diseases, the expanded CAG repeat diseases. While the cellular aggregation process undoubtedly depends on the flux and local environment of these proteins, their intrinsic physical p...

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Hlavní autoři: Jayaraman, Murali, Thakur, Ashwani K., Kar, Karunakar, Kodali, Ravindra, Wetzel, Ronald
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057327/
https://ncbi.nlm.nih.gov/pubmed/21232603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2011.01.001
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