Slow Amyloid Nucleation via α-Helix-Rich Oligomeric Intermediates in Short Polyglutamine-Containing Huntingtin Fragments

The 17-amino-acid N-terminal segment (htt(NT)) that leads into the polyglutamine (polyQ) segment in the Huntington's disease protein huntingtin (htt) dramatically increases aggregation rates and changes the aggregation mechanism, compared to a simple polyQ peptide of similar length. With polyQ...

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Autores principales: Jayaraman, Murali, Kodali, Ravindra, Sahoo, Bankanidhi, Thakur, Ashwani K., Mayasundari, Anand, Mishra, Rakesh, Peterson, Cynthia B., Wetzel, Ronald
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568928/
https://ncbi.nlm.nih.gov/pubmed/22178474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.12.010
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