Inhibiting nucleation of amyloid structure in a huntingtin fragment by targeting α-helix rich oligomeric intermediates

Although oligomeric intermediates are transiently formed in almost all known amyloid assembly reactions, their mechanistic roles are poorly understood. Recently we demonstrated a critical role for the 17 amino acid N-terminal segment (htt(NT)) of huntingtin (htt) in oligomer-mediated amyloid assembl...

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Main Authors: Mishra, Rakesh, Jayaraman, Murali, Roland, Bartholomew P., Landrum, Elizabeth, Fullam, Timothy, Kodali, Ravindra, Thakur, Ashwani K., Arduini, Irene, Wetzel, Ronald
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267848/
https://ncbi.nlm.nih.gov/pubmed/22178478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.12.011
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