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Serine phosphorylation suppresses huntingtin amyloid accumulation by altering protein aggregation properties
Aggregation of expanded polyglutamine (polyQ) repeat containing fragments of the huntingtin (htt) protein may play a key role in Huntington’s disease (HD). Consistent with this hypothesis, two Ser to Asp mutations in the 17 amino acid N-terminal htt(NT) segment abrogate both visible brain aggregates...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3488119/ https://ncbi.nlm.nih.gov/pubmed/22999956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.09.011 |
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