Serine phosphorylation suppresses huntingtin amyloid accumulation by altering protein aggregation properties

Aggregation of expanded polyglutamine (polyQ) repeat containing fragments of the huntingtin (htt) protein may play a key role in Huntington’s disease (HD). Consistent with this hypothesis, two Ser to Asp mutations in the 17 amino acid N-terminal htt(NT) segment abrogate both visible brain aggregates...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Mishra, Rakesh, Hoop, Cody L., Kodali, Ravindra, Sahoo, Bankanidhi, van der Wel, Patrick C. A., Wetzel, Ronald
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488119/
https://ncbi.nlm.nih.gov/pubmed/22999956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.09.011
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky