Serine phosphorylation suppresses huntingtin amyloid accumulation by altering protein aggregation properties

Aggregation of expanded polyglutamine (polyQ) repeat containing fragments of the huntingtin (htt) protein may play a key role in Huntington’s disease (HD). Consistent with this hypothesis, two Ser to Asp mutations in the 17 amino acid N-terminal htt(NT) segment abrogate both visible brain aggregates...

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Main Authors: Mishra, Rakesh, Hoop, Cody L., Kodali, Ravindra, Sahoo, Bankanidhi, van der Wel, Patrick C. A., Wetzel, Ronald
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488119/
https://ncbi.nlm.nih.gov/pubmed/22999956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.09.011
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