Polyglutamine disruption of the huntingtin exon1 N-terminus triggers a complex aggregation mechanism

Simple polyglutamine (polyQ) peptides aggregate in vitro via a nucleated growth pathway directly yielding amyloid-like aggregates. We show here that the 17 amino acid flanking sequence (htt(NT)) N-terminal to the polyQ in the toxic huntingtin exon1 fragment imparts onto this peptide a complex altern...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Thakur, Ashwani K., Jayaraman, Murali, Mishra, Rakesh, Thakur, Monika, Chellgren, Veronique M., Byeon, In-Ja, Anjum, Dalaver H., Kodali, Ravindra, Creamer, Trevor P., Conway, James F., M.Gronenborn, Angela, Wetzel, Ronald
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706102/
https://ncbi.nlm.nih.gov/pubmed/19270701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1570
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items