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Mutational analysis of the structural organization of polyglutamine aggregates

The formation of amyloid-like aggregates by expanded polyglutamine (polyGln) sequences is suspected to play a critical role in the neuropathology of Huntington's disease and other expanded CAG-repeat diseases. To probe the folding of the polyGln sequence in the aggregate, we replaced Gln–Gln pa...

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Sonraí Bibleagrafaíochta
Main Authors: Thakur, Ashwani K., Wetzel, Ronald
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2002
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC139261/
https://ncbi.nlm.nih.gov/pubmed/12444250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.252523899
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