Calpain Activation in Huntington's Disease

por Gafni, Juliette, Ellerby, Lisa M.
Publicado en J Neurosci (2002)

Calpain-1 Cleaves and Activates Caspase-7

por Gafni, Juliette, Cong, Xin, Chen, Sylvia F., Gibson, Bradford W., Ellerby, Lisa M.
Publicado 2009

FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease

por Jin, Kunlin, LaFevre-Bernt, Michelle, Sun, Yunjuan, Chen, Sylvia, Gafni, Juliette, Crippen, Danielle, Logvinova, Anna, Ross, Christopher A., Greenberg, David A., Ellerby, Lisa M.
Publicado 2005

Identification and Evaluation of Novel Small Molecule Pan-Caspase Inhibitors in Huntington’s Disease Models

por Leyva, Melissa J., DeGiacomo, Francesco, Kaltenbach, Linda S., Holcomb, Jennifer, Zhang, Ningzhe, Gafni, Juliette, Park, Hyunsun, Lo, Donald C., Salvesen, Guy S., Ellerby, Lisa M., Ellman, Jonathan A.
Publicado 2010

Proteolysis of Mutant Huntingtin Produces an Exon 1 Fragment That Accumulates as an Aggregated Protein in Neuronal Nuclei in Huntington Disease

por Landles, Christian, Sathasivam, Kirupa, Weiss, Andreas, Woodman, Ben, Moffitt, Hilary, Finkbeiner, Steve, Sun, Banghua, Gafni, Juliette, Ellerby, Lisa M., Trottier, Yvon, Richards, William G., Osmand, Alex, Paganetti, Paolo, Bates, Gillian P.
Publicado 2010

Matrix Metalloproteinases are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington’s Disease

por Miller, John P., Holcomb, Jennifer, Al-Ramahi, Ismael, de Haro, Maria, Gafni, Juliette, Zhang, Ningzhe, Kim, Eugene, Sanhueza, Mario, Torcassi, Cameron, Kwak, Seung, Botas, Juan, Hughes, Robert E., Ellerby, Lisa M.
Publicado 2010

A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease

por Miller, John P., Yates, Bridget E., Al-Ramahi, Ismael, Berman, Ari E., Sanhueza, Mario, Kim, Eugene, de Haro, Maria, DeGiacomo, Francesco, Torcassi, Cameron, Holcomb, Jennifer, Gafni, Juliette, Mooney, Sean D., Botas, Juan, Ellerby, Lisa M., Hughes, Robert E.
Publicado 2012

Caspase-6 Activity in a BACHD Mouse Modulates Steady-State Levels of Mutant Huntingtin Protein But Is Not Necessary for Production of a 586 Amino Acid Proteolytic Fragment

por Gafni, Juliette, Papanikolaou, Theodora, DeGiacomo, Francesco, Holcomb, Jennifer, Chen, Sylvia, Menalled, Liliana, Kudwa, Andrea, Fitzpatrick, Jon, Miller, Sam, Ramboz, Sylvie, Tuunanen, Pasi I., Lehtimäki, Kimmo K., Yang, X. William, Park, Larry, Kwak, Seung, Howland, David, Park, Hyunsun, Ellerby, Lisa M.
Publicado 2012

Caspase Cleavage of Mutant Huntingtin Precedes Neurodegeneration in Huntington's Disease

por Wellington, Cheryl L., Ellerby, Lisa M., Gutekunst, Claire-Anne, Rogers, Danny, Warby, Simon, Graham, Rona K., Loubser, Odell, van Raamsdonk, Jeremy, Singaraja, Roshni, Yang, Yu-Zhou, Gafni, Juliette, Bredesen, Dale, Hersch, Steven M., Leavitt, Blair R., Roy, Sophie, Nicholson, Donald W., Hayden, Michael R.
Publicado en J Neurosci (2002)